Set alongside the River Croal and between St Peters Way (A666), Bank Street, Manor Street and Folds Road, the under-used site is set to be transformed.
Muse said the regeneration of Church Wharf will create a distinctive new area of the town in an attractive riverside setting.
Residents and visitors will also be able to enjoy green, open space with plans to improve the river setting and build a new footbridge linking the site to Bank Street.
Church Wharf is part of Bolton Council’s £1bn master plan to transform the town centre.
David Burkinshaw, Development Director at Muse Developments, said: “Cities and towns across the North are being revitalised as more people choose to live in urban centres.
“This shift in the way people want to live is enabling new neighbourhoods to be created with a daytime and evening economy, where restaurants, bars, cafes and shops all thrive.
“The Church Wharf site is in an ideal location for new homes, within minutes’ walk of the centre of town. The setting alongside the River Croal and with impressive views of the two churches gives Muse the opportunity, working in partnership with Bolton Council, to create something really special that people can be proud of.”